LIBRARY.SE is a Swedish open digital library, repository of author's heritage and archive

Register & start to create your original collection of articles, books, research, biographies, photographs, files. It's convenient and free. Click here to register as an author. Share with the world your works!

ANTITUMOR DRUGS: A NEW APPROACH
by Acad. Georgi GEORGIEV and Alexandr SOBOLEV, Dr. Sc. (Biol.), Institute of Gene Biology, Russian Academy of Sciences The main problem of drug treatment of cancer using chemo-, radio, photodynamic therapy or other methods is in grave side effects from which the patients suffer. All types of cancer cell exposure unfortunately involve normal, intensely dividing cells with the same characteristics. The task of scientists is to increase the selectivity of drug action. This can be attained by drug delivery to transformed cells by means of multimodular carriers. THERAPEUTIC EFFECT OF LIGHT Therapeutic and diagnostic methods based on recent progress in photochemistry, photobiology, nuclear physics and chemistry have been ever more often used in oncology in these two last decades. One promising approach is offered by photodynamic therapy (PDT), when a photosensitizer drug accumulated in the tumor destroys it by absorbing the irradiating light. The photosensitizer proper is nontoxic for the malignant tumor, but the so-called active oxygen forms (AOF), appearing during its illumination in the presence of O2, are destructive: these are singlet oxygen (1O2), hydroxyl radical (•OH), and others; many molecules in the cell (proteins, lipids, nucleic acids) and supramolecular structures formed by them serve as targets for AOF. An intricate succession of photochemical and photobiological processes leads to irreversible damage to cancer tumor cells and/or vessels. As it often happens, the idea of using light-activated chemical compounds for the treatment of various diseases is not new. Vitiligo (skin disease) was treated in ancient Egypt using plants containing psoralenes* and sunlight. Recently (in 1903) a Danish scientist Niels R. * Psoralenes are natural photosensitizers contained in extracts from seeds of umbellate plants (Ammi majus L.) and legumes (Psoralea corylifolia L.) and their synthetic analogs. - Auth. стр. 40 F ... Read more
____________________

This publication was posted on Libmonster in another country. The article seemed interesting to our editor.

Full version: http://libmonster.com/m/articles/view/ANTITUMOR-DRUGS-A-NEW-APPROACH
Sweden Online · 366 days ago 0 139
Link
Permanent link to this publication:

http://library.se/blogs/entry/ANTITUMOR-DRUGS-A-NEW-APPROACH


© library.se
Professional Authors' Comments:
Order by: 
Per page: 
 
  • There are no comments yet
Guest comments




Actions
Rate
0 votes

Publisher
Sweden Online
Stockholm, Sweden
20.10.2018 (366 days ago)
 


Who Like this
Likes · Dislikes
 
Empty
ONE WORLD -ONE LIBRARY
Libmonster is a free tool to store the author's heritage. Create your own collection of articles, books, files, multimedia, and share the link with your colleagues and friends. Keep your legacy in one place - on Libmonster. It is practical and convenient.

Libmonster retransmits all saved collections all over the world (open map): in the leading repositories in many countries, social networks and search engines. And remember: it's free. So it was, is and always will be.


Click here to create your own personal collection
ANTITUMOR DRUGS: A NEW APPROACH
 

Support Forum · Editor-in-chief
Watch out for new publications:

About · News · Reviews · Contacts · For Advertisers · Donate to Libmonster

Swedish Digital Library ® All rights reserved.
2014-2019, LIBRARY.SE is a part of Libmonster, international library network (open map)


LIBMONSTER - INTERNATIONAL LIBRARY NETWORK